Watch NET formation with time-lapse imaging of neutrophils.
Neutrophil Defensive NETworks
Neutrophils play a critical role in the engulfment and destruction of invasive pathogenic microorganisms. One means by which they do this is to extrude web-like neutrophil extracellular traps (NETs) in response to infectious challenge. NETs are composed of DNA histones and multiple antimicrobial agents (e.g., myeloperoxidase (MPO), elastase, defensins, etc.). Cayman has developed several tools to study the process of NETosis.